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AIMECS 07
ORGANIZED BY
Asian Federation for Medicinal Chemistry [AFMC]
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| SPONSORED BY |
| International Union of Pure and Applied Chemistry (IUPAC) |
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| The Scientific and Technological Research Council of Turkey (TUBITAK) |
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MANAGED BY
The Computer Aided
Drug Design & Development
Society in Turkey (CADD&D)
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Final Programme
12:00 – 16:30 |
REGISTRATION
At the Venue Place : The Marmara Istanbul Hotel |
GRANDBALL ROOM
16:30 – 17:30 |
OPENING CEREMONY
Chairing by
Ismail YALCIN (AFMC President & Symposium
Chairman,
Turkey
)
Esin AKI(SENER) (AIMECS 07 Organization Committee
Chair,
Turkey
)
|
17:30 – 18:30 |
OPENING LECTURE
By
Toshi-Hiko KOBAYASHI,
AFMC Past President, PhRMA (
USA
), Japan
“Strategy-Life
Cycle Management of Drugs” |
18:30 – 19:30 |
CULTURAL EVENT
Show for the 800th Anniversary
of the Birth of Mevlana Celaleddin-i Belhi-Rumi, Poet and Philosopher
(Celebration
of anniversary which UNESCO is associated for the Year of 2007) |
19:30 - 21:00 |
WELCOME COCKTAIL
(The Marmara Istanbul Hotel) |
GRANDBALL ROOM |
Plenary Lecture
Chair; Toshi-Hiko KOBAYASHI
(AFMC Past President,
Japan
) |
09:00 - 09:50
PL-1 |
“Synthesis of Pharmaceuticals through Asymmetric Two-center Catalysis”
Masakatsu SHIBASAKI,
(Nobel Prize Canditate)
The
University of
Tokyo,
Japan
|
09:50 - 10:15 |
Coffee Break |
SESSION 1
GRANDBALL ROOM |
Biosynthetic Medicinal Chemistry (ACS
Session)
Chair: Frank E. KOEHN
(Director- Natural Products, Wyeth Research,
U.S.A.
) |
10:15 - 10:50
IL-1 |
“Synthesis, SAR, and
Preclinical Evaluation of Marine Natural Products that Modulate PI3Kinase
Signaling”
Raymond J. ANDERSEN,
University of
British Columbia,
Vancouver,
Canada
|
10:50 - 11:10
OP-1 |
“Combinatorial Biosynthesis: A New Tool for
Developing Structural Diversity in Natural Products”
Jose A. SALAS,
University of Oviedo,
Spain
|
11:10 - 11:30
OP-2 |
“Combinatorial
Biosynthesis and Studies on Biosynthetic Key Enzymes - Perspectives for Drug
Discovery”
Jurgen ROHR,
University of
Kentucky,
Lexington,
U.S.A.
|
11:30 - 11:50
OP-3 |
“Towards
'best-in-class' Hsp90 Inhibitors: A Synthetic Biology Approach”
Ming-Qiang ZHANG,
Biotica
Technologies, Ltd.,
Cambridge,
U.K.
|
11:50 - 12:10
OP-4 |
“Directed
Biosynthesis and SAR of Mannopeptimycins”
Frank E. KOEHN
Director-
Natural Products, Wyeth Research,
U.S.A.
|
12:10 – 12:30
OP-5 |
“Structural Elucidation of Cyclodextrin Inclusion
Complexes of Novel Allicin-mimics”
Mino CAIRA,
University of Cape Town,
South Africa
|
SESSION 2
TAKSIM HALL |
Protein-Protein Interactions (EFMC Session)
Chair: Ferran SANZ
(EFMC Past President, University Pompeu Fabra,
Barcelona, Spain) |
10:15 - 10:50
IL-2 |
“Protein-Protein Interactions”
Patrick CHENE,
Oncology
Department, Novartis,
Basel,
Switzerland
|
10:50 - 11:10
0P-6 |
“Assessing the Drug Ability of Protein-Protein Interactions”
Xavier
BARRIL,
Barcelona
University,
Spain
|
11:10 - 11:30
OP-7 |
“Association
of Protein Bindings Sites with Fluctuation Behavior of Residues”
Turkan HALILOGLU,
Bogazici
University,
Istanbul,
Turkey
|
11:30 - 11:50
OP-8 |
“Fragment-based Approaches to Inhibitor Discovery: Targeting Cofactor-binding
Sites and Protein-Protein Interactions”
Alessio CIULLI,
University
of Cambridge,
U.K.
|
11:50 - 12:10
OP-9 |
“NMR
Study on Membrane proteins-ligands Interactions”
Ichio. SHIMADA
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan |
12:10 – 12:30
OP-10 |
“Insight into the Folding Inhibition of HIV-1 Protease by a Small Peptide”
Massimiliano
BONOMI,
Department of Chemistry and Applied Biosciences, ETH
Zurich,
Switzerland
|
13:30 – 15:30
ANADOLU HALL |
Poster Session
(Group A) |
SESSION 3
GRANDBALL ROOM |
Predictive in silico Methods
Chair: Renate GRIFFITH,
(
University
of Newcastle,
Australia
) |
15:30 - 16:05
IL-3 |
“Predictive QSAR Modeling Workflow and its Application
to Support the Experimental Discovery of Biologically Active Compounds”
Alex TROPSHA,
University
of North Carolina,
U.S.A.
|
16:05 – 16:25
OP-11 |
“Molecular Modelling as a Tool for the Design of Drug Candidates”
Maurizio BOTTA
University of Siena,
Italy
|
16:25 – 16:45
OP-12 |
“Modeling Strategies Used to Support the Discovery of Caspase-3
Inhibitors”
Gregory J. TAWA
Wyeth
Research,
U.S.A.
|
16:45 - 17:05
OP-13 |
“Molecular
Modelling Studies on Some Eukaryotic Topoisomerase II Enzyme Inhibitor Fused Heterocyclic Compounds”
Ilkay YILDIZ
Faculty
of Pharmacy,
Ankara
University,
Ankara,
Turkey
|
17:05 - 17:35 |
Coffee Break |
17:35 - 17:55
OP-14 |
“A Fast Empirical Scoring Method for Docking and Virtual Screening”
Pietro COZZINI,
University of Parma,
Italy
|
17:55 – 18:15
OP-15 |
“A Comparative Molecular Field Analysis (CoMFA) Study of Flavonoids
Active Against HT-29
Colon
Carcinoma”
Bo Cheng WANG,
Tamkang University,
Taiwan
|
18:15 – 18:35
OP-16 |
“Modelling Ligand Selectivity: an Integrated Approach”
Vladimir A.
Palyulin
Department
of Chemistry,
Moscow State
University,
Russia
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SESSION 4
TAKSIM HALL |
Natural Products with Biological/Physiological Activities
Chair: Toshio FUJITA
(Kyoto
University, Japan) |
15:30 - 16:05
IL-4 |
“Cancer Preventive Food Phytochemicals: Screening, Animal Model
Studies and Possible Action Mechanisms”
Hajime OHIGASHI,
Fukui Prefectural University,
Japan
|
16:05 – 16:25
OP-17 |
“Anti-dementia
Compounds from the Mushroom Hericium
erinaceum”
Hirokazu
KAWAGISHI,
Graduate
School of Science and Technology ,
Shizuoka University,
Japan
|
16:25 – 16:45
OP-18 |
Phagocytosis of Polymer Microspheres by Alveolar Macrophages for
Overcoming Tuberculosis
Hiroshi TERADA
Tokyo
University of Science,
Japan
|
16:45 - 17:05
OP-19 |
“Small
Molecule Potassium-Channel Blockers As Potential Treatments for Autoimmune
Disease”
Jonathan B. BAELL,
The Walter and Eliza Hall Institute of Medical
Research,
Australia
|
17:05 - 17:35 |
Coffee Break |
17:35 - 17:55
OP-20 |
“Recent Progress in Biosynthetic
Studies on Bioactive Triterpenoid Saponins”
Yutaka EBIZUKA,
University of Tokyo, Japan |
17:55 – 18:15
OP-21 |
“Composition and Antioxidant Activities of Polysaccharides from Mycelial Culture of a Medicinal Fungus Cordyceps sinensis Cs-HK1”
Jian-Yong WU,
The Hong Kong Polytechnic University, Hong Kong
|
GRANDBALL
ROOM
08:45 - 09:00 |
Plenary Lecture
Chair; David WINKLER
(President-Elect
of AFMC,
Australia
)
Introduction of the AIMECS 09 Meeting in
Australia
by
Chair |
09:00 - 09:50
PL-2 |
“Structural Insights into
Ligand-Induced Activation of the Insulin Receptor”
Colin WARD,
CSIRO
Molecular & Health Technologies,
Australia
|
09:50 - 10:15 |
Coffee Break |
SESSION 5
GRANDBALL
ROOM |
Intellectual Property and Regulatory
Affairs
Chair: Koichi HIRAI
(Sankyo Co. Ltd.,
Tokyo,
Japan
) |
10:15 - 10:55
IL-5 |
“How to ensure Safety of Drugs-Efforts by
Japan
’s Ministry of Health,
Labour, and Welfare (MHLW)-”
Hisayoshi MORIOKA
Pharmaceuticals and Food Safety Bureau, Ministry of Health, Labour, and Welfare, Japan
|
10:55 - 11:30
OP-22 |
“Intersection of
Regulatory Requirements and Intellectual Property Rights”
Mark PAXTON,
Associate
Vice President,
PhRMA,
U.S.A.
|
11:30 - 12:00
OP-23 |
“Regulatory Delays
and Patent Terms”
Michael J. CAINE,
Davies Collison Cave, Melbourne, Australia |
12:00 - 12:30
OP-24 |
Intellectual
Property Rights in the Pharmaceutical Industry:Turkish Experience
Hülya CAYLI
Paragaon Consultancy Incorporated, Ankara, Turkey |
SESSION 6
TAKSIM HALL |
Novel Drug Targets as a
Basis for New Drug Development
Chair: Young-Ger SUH,
(
Seoul
National
University,
Seoul,
Korea
) |
10:15 - 10:50
IL-6 |
“Development of Novel
Clinical Candidates Targeting A3 Adenosine Receptor”
Lak Shin JEONG,
College of
Pharmacy,
Ewha
Womans
University,
Seoul,
Korea
|
10:50 - 11:10
OP-25 |
“Triazole Analogue of the Immunostimulant α-Galactosylceramide
(KRN7000): Synthesis and Evaluation”
Sanghee KIM
College of
Pharmacy,
Seoul National University,
Korea
|
11:10 - 11:30
OP-26 |
“Small-Molecule Inhibition of Siderophore
Biosynthesis in Mycobacterium tuberculosis and Yersinia pestis”
Jae-Sang RYU,
College of
Pharmacy,
Ewha
Womans
University,
Seoul,
Korea
|
11:30 - 11:50
OP-27 |
“Udenafil, A New Long Acting PDE5 Inhibitor”
Moohi YOO
Research
Laboratories, Dong-A Pharmaceutical Co.,
Korea
|
11:50 - 12:10
OP-28 |
“Molecular Dynamics Simulations of HIV-1 Protease Monomer: Assembly of
N-terminus and C-terminus into
β-Sheet in Water Solution”
Mao-Sheng CHENG,
Shenyang
Pharmaceutical
University,
Shenyang,
China
|
12:10 – 12:30
OP-29 |
“Therapeutic Potential of the
Potent BKCa Channel Openers: Synthesis, SAR, Mechanism of Action
and Pharmacological Evaluation of Benzofuroindole Analogues”
Yong-Chul KIM,
Gwangju Institute of Science and
TechnologyGwangju,
Korea
|
13:30 – 15:30
ANADOLU HALL |
Poster Session
(Group B) |
SESSION 7
GRANDBALL
ROOM |
Biomarkers in HTS through Preclinical
& Clinical Development
Chair: Norio MATSUKI
(The
University of Tokyo, Japan) |
15:30 - 16:05
IL-7 |
“Acrolein as a Novel Biochemical Marker for Cerebral Stroke and Silent
Brain Infarction”
Kazuei IGARASHI,
Graduate
School of Pharmaceutical Sciences,
Chiba University,
Japan
|
16:05 – 16:25
OP-30 |
“Development of Bioimaging Fluorescent Probes Based on Photo-induced
Electron Transfer”
Tetsuo
NAGANO,
Graduate
School of Pharmaceutical Sciences,
University of Tokyo,
Japan
|
16:25 – 16:45
OP-31 |
“Efficient Fluorescence Assay for Serine/Threonine
Kinases”
Naoki UMEZAWA
Graduate
School of
Pharmaceutical Sciences,
Nagoya City
University,
Japan
|
16:45 – 17:05
OP-32 |
“Hydrogen Peroxide Regulates Synaptic Plasticity in the Hippocampus”
Norio MATSUKI,
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
|
17:05 - 17:35 |
Coffee Break |
17:35 - 17:55
OP-33 |
“High-Throughput Repurposing and Its Application to the Study of Angiotensin AT1 Antagonists”
David ARAGONES,
Prous Institute for Biomedical Research, Barcelona, Spain
|
17:55 - 18:15
OP-34 |
“Development of Benzofurazan Labeling Reagents for LC/MS/MS and Their Application to Biomarker Analysis”
Tomofumi SANTA,
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
|
SESSION 8
TAKSIM HALL |
New Methods for Drug Discovery
Chair: Alex TROPSHA
(
University of North Carolina,
U.S.A.
) |
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